Whole-body vibration effects in patients affected with Parkinson's disease: a systematic literature review
Efectos de las vibraciones mecánicas de cuerpo completo en pacientes afectados por la enfermedad de Parkinson: una revisión sistemática de la literatura
B.. del Pozo-Cruz a , J.C.. Adsuar a , J.A.. Parraca a , P.R.. Olivares a , E.. Herrera b , N.. Gusi c
a Faculty of Sports Sciences. University of Extremadura. Caceres. Spain.
b Enterprising Solutions for Health (E & H). Badajoz. Spain.
c Faculty of Sports Sciences. University of Extremadura. Caceres. Spain. Enterprising Solutions for Health (E & H). Badajoz. Spain.
Resumen
Parkinson's disease (PD) is a common progressive bradykinetic disorder, although ethiopathogenic is unknown, can be accurately diagnosed. However neuroprotectors treatment had been improve in the last decades, to date it's far of handicap motor control in this illness, for this cause, it's very necessary the addiction of other therapies as regular physical activity, in order to improve gait, balance, postural asymmetries or muscle power. The objective was to evaluate volume and methological quality by existing studies in relation to the topic, testing the effects produced by whole body vibration (WBV) in PD. An electronic search literature of the main medicine databases (AMED, The Cochrane Library, GoogleSchoolar, MEDLINE, PEDro, PubMed, SPORT discus, TRIP database and Web of Science) was performed to identify studies published up to 1 of June 2009 that investigated the effects of WBV exercises in patients with PD. A total of 5 studies were selected and analyzed by PD. Main outcome measurements were gait, posture, balance and health related quality of life. In general, there is a poor evidence of the benefices effects of WBV exercise in patients with Parkinson's disease in outcome measurements. Future researches in this approach it is strongly necessary to answer it.
Resumen
La enfermedad de Parkinson (EP) supone una alteración bradicinésica progresiva y aunque su etiopatogenia es desconocida, se puede diagnosticar de forma precisa. Aunque el tratamiento basado en neuroprotectores ha mejorado en las últimas décadas, hasta la fecha el inconveniente del control motor en esta enfermedad sigue existiendo; por esta razón es muy necesaria la adición de otras terapias como la actividad física regular, con el fin de mejorar la marcha, el equilibrio, las asimetrías posturales o la fuerza muscular. El objetivo del presente trabajo fue evaluar el volumen y la calidad metodológica de los estudios existentes en relación con el tema, así como analizar las evidencias existentes sobre los efectos producidos por la vibración de cuerpo entero (WBV) en la EP. Se realizó una búsqueda bibliográfica electrónica en las principales bases biomédicas existentes (AMED, The Cochrane Library, GoogleSchoolar, MEDLINE, PEDro, PubMed, SPORT discus, TRIP database y Web of Science) para identificar los estudios publicados hasta el 1 de junio de 2009 que investigaron los efectos de los ejercicios con WBV en pacientes con EP. Se seleccionaron y analizaron un total de 5 artículos relacionados con la enfermedad de Parkinson. Las medidas principales fueron la marcha, la postura, el equilibrio y la salud relacionada con la calidad de vida. En general, hay una escasa evidencia de los efectos beneficiosos del ejercicio con WBV en pacientes con EP a partir de los resultados obtenidos. Son necesarias futuras investigaciones sobre el tema para responder a los interrogantes existentes.
Palabras clave
Rehabilitación, Terapia física, Enfermedad neurológica, Temblor, Bradicinesia
Keywords
Rehabilitation, Physical therapy, Neurological diseases, Temblor, Bradykinesia

Introduction

Parkinson's disease (PD) is a progressive movement disorder that is accompanied by bradykinesia and may be diagnosed precisely.It is characterized by the occurrence of a severe nigral cell loss in the pars-compacta, and an accumulation of alpha-synuclein in the cerebral trunk, spinal medulla and cortical regions1.

The etiopathogenesis of PD is not known with certainty, although we know that genetic predisposition exists2,3, and that age is a risk factor, since the prevalence of PD increases with age, for example incidence increases by 0.3% each year for every 1,000 persons aged between of 55 and 65, and 4.4% each year for every 1,000 persons aged 85 and above. Apparently men have a greater risk of suffering from PD than do women (the ratio between affected men and women being 1.54; 95% IC, 0.95 to 2.51)4,5.

The main motor symptoms of PD are tremors, rigidity, bradykinesia, akinesia, and problems with balance and gait6,7. These symptoms have an effect upon the health-related quality of life (HRQoL)8 affecting physical, psychological, social and functional well-being9; presenting a lower level of physical activity10, bone mass11, strength12, skills and balance13 than in healthy peers14, whereby this population has a threefold greater risk of falls followed by fractures than do persons not suffering from this disease15,16.

PD is marked by a deficit of dopamine supply, so that the most common treatment therapy is based on the replacement of this neurotransmitter17,18. Although neuroprotective treatments have advanced greatly, we are still very far off from being able to control motor handicap, so that the addition of other therapies, such as regular physical activity, which may contribute to improving gait, postural asymmetries, balance and increasing muscular strength is highly necessary19.

Even though some physical therapeutic treatment recommendations20 exist for each of the stages that PD passes through21, initiatives for studying the cost-effectiveness and cost-utility of these therapies are rare indeed22. However, this type of studies does exist for pharmacologic therapies23, along with other types24.

In the last decade of the previous century, the use of whole body vibration (WBV) for improving performance and therapy had surged tremendously25. However, the beneficial effects of vibration in patients with nervous-system disorders had already been observed by neurologists, such as Martin Charcot26, at the beginning of this century, thus paving the way for studies related to the harmful effects of exposure to vibration in the workplace27.

Although, in recent years, the use of WBV has seen an increase in popularity, the mechanism responsible for the resulting benefits remains unclear. It is generally believed that WBV stimulates subcutaneous proprioceptors, the spinal circuit being the first phase in the feedback motor loop for generating rapid efferent reactions in response to proprioceptive input, thereby producing a tonic vibration reflex28, although central projection of the supraspinal motor centres also controls these reactions, thereby increasing corticospinal excitability and producing an alteration of the intracortical processes that are exclusively related to exercise29.

The majority of studies with healthy individuals has demonstrated WBV as a method for increasing physical capacity30, hormonal production31, bone mass32, balance, proprioception, and HRQoL33. However, a growing number of studies have been published for specific populations, for example adults, post-menopausal women, or persons with neurological disorders34-46. Along with the increasing number of studies on the effects of WBV, systematic reviews related to the treatment and training of healthy individuals47-49, specific populations50, and neurological pathologies have begun to emerge. However, we have no knowledge of any systematic reviews on the effects of WBV in PD.

The aim of the present systematic review is to evaluate, at the risk of bias, the volume and methodological quality of clinically relevant studies existing up until June 1, 2009, and examine the effects obtained by WBV in patients affected by PD.

Methods

In producing our systematic reviews, we used the PRISMA methodology51.

Applied resources

Studies were identified by searching the following electronic databases of recognized quality, scanning the lists of articles reported there: AMED (2005 to the present), The Cochrane Library (2003 to the present), GoogleSchoolar (2003 to the present), MEDLINE (2000 to the present), PEDro (2003 to the present), PubMed (1973 to the present), SPORTdiscus (2002 to the present), TRIP database (2002 to the present), and Web of Science (1988 to the present). The ISRCTN database was scanned beginning from January 1, 2008, and until July 1, 2009, for the purpose of locating future studies of relevance to the current topic and entered there.

Article selection

Selection of the databases, search strategy and list of terms, including their combinations, was done by medical library science experts and experts in the field of WBV applied to PD in order to locate the articles reported in the present systematic review. The search was completed July 1, 2009, with no submission deadline imposed on the experts.

The articles were located by using a combination of terms, ranging from WBV training or therapy to PD, accurately using the Boolean operators (AND, OR, NOT) in order to scan all underlying articles of relevance to the topic. A detailed list of terms and combination formulas is available from the authors of the present study. Duplicate articles were manually removed by one of the authors taking part in the initial review process. In figure 1, the flow chart of the complete process for the system review appears. Articles of the present study were indexed, if they matched the following inclusion criteria: a) treatment or training with WBV, b) aimed at individuals with PD, c) randomized and non-randomized clinical studies, d) studies with and without a control group in order to compare the effects of the treatment or training, e) published exclusively in English, and f) original articles of clinical studies. Articles were excluded, if they matched the following criteria: a) effects of exposure to vibration if studied within industry, labour employment and transport, b) aimed at animals and persons not presenting PD, c) one-time presentation of a summary at a conference, congress, critical treatise or seminar, d) presented in a language other than English, and e) reviews. Article selection was done by two experts independent of the standard method (with no double-blind controls), and resolving potential disagreements through mutual consensus. However, if this was impossible, direct contact with the original author of a certain manuscript was obtained via e-mail or telephone, as appropriate.

Fig. 1. Flow diagram of systematic review process.

Risk of bias

In order to assess the risk of bias in the studies that were included in the current systematic review, we used the Physiotherapy Evidence Database (PEDro) scale. We chose this scale due to its special design and ability to provide a global view of the external and internal validity of the studies included in the present systematic review, and after reviewing its repeatability and utility52. Each article was graded independently by two reviewers participating in the study, reporting a high degree of intra-class coefficient correlation (0.92). There were no significant disagreements among the advisors (p = 0.9).

Level of evidence

The level of evidence was reported in accordance with the guidelines of the German Institute for Healthcare Improvement (CBO)53.

Data extraction process and the outcome measurements used in this review. Analysis

The extraction of data from the selected articles was done by one author of the present review and subsequently checked by another, discussing potential disagreements among them, and finally allowing a third author to resolve any disagreements, when the original author of the manuscript submitted for discussion could not be contacted. The information was extracted separately from each selected manuscript, stating: a) participant characteristics (age and gender), b) degree of severity, duration and pharmacological patient dose, c) type of intervention (including type of machine, oscillation, frequency, amplitude, duration of intervention, series number and intervening rest periods, exposure time per series, body posture, knee angle and number of WBV sessions). An identical procedure followed in order to assess the key measurements contained in the individual reviewed articles and finally included in the present study. The key measurements presented were: a) balance, b) gait, c) postural control, d) proprioception, and e) HRQoL; using various measurements for the same physical quality in accordance with the article. These measurements were evaluated on the basis of the effect produced by WBV reported by the original author, and determined according to: a) ↑ improvement in the exercise group (p < .05), b) ↓ improvement in the control group (p < .05), c) = absence of significant differences, d) * unreported or non-existent data, and e) Δ significant intra-group, pre- and post-test differences.

Results

Article selection

Figure 1 shows the complete process that was followed in the systematic review. An electronic search of AMED (4), the Cochrane Library (11), GoogleSchoolar (281), MEDLINE (5), PEDro (1), PubMed (5), SPORTdiscus (3), TRIP database (0), Web of Science (10), and ISRCTN (0) yielded a total of 309 citations. A number of 289 citations were reviewed after removing duplicates. Of these, a total of 279 publications were rejected for inclusion in the systematic review, since having reviewed their summaries, they evidently did not match the proposed inclusion criteria. Five studies were subjected to a more in-depth analysis, since it was not clear from their summaries, whether or not they matched the inclusion criteria, and they were subsequently eliminated due to the following reasons: Full text not provided (n = 3), written in a language other than English (n = 1), and dealt with systematic reviews (n = 1). A total of 5 articles were identified for inclusion in the current systematic review.

Risk of bias

Table 1 provides the scores of each reviewed study, in which 3 studies were randomized and 2 were not. The scores on the PEDro scale varied between 2 and 7, the average being 4.60, and the standard deviation ±1.81. The lowest scores were given to items referring to the ignorance as to which group each patient corresponded to (assessors and therapists), where this was referenced by only two studies, and ignorance (by a patient) as to which group he/she belonged to, where no study made reference to assignment ignorance. On the other hand, an «intent-to-treat» analysis was not provided by any study. In the statistical field, 2 studies provided detailed measurements along with their variability, while 2 thereof made no reference to these measurements. Four of the reviewed studies provide inter-group comparisons, whereas only one study does not. All the studies provide participant characteristics, along with the inclusion and exclusion criteria defined by each study.

Level of evidence

Table 1 shows the level of evidence for each study. Two studies present a level of evidence B, and three studies present a level of evidence C. The level of evidence of the topic discussed in the review was 3, in conformance with CBO53.

Study characteristics

Table 2 captures the characteristics of the articles reviewed according to the theoretical approach reported internationally in health care, PICOS (Participants, Intervention, Control, Outcome Measurements and Study design)54.

Patients

The age of reviewed study participants varied between 63.1 ± 7.3 and 75.0 ± 6.8. Most of the patients presented in the studies were of male gender (above 50% in each reviewed study). The minimum sample contained 27 patients, and the maximum 68. The degree of severity varied from II to IV according to the Hoehn & Yahr (H&Y) scale21. The dopamine dose varied from 325 (± 122) to 600 (± 207.0) mg/d. The duration of the disease varied from 5.9 ± 4.6 to 8.5 ± 0.7 years.

Whole body vibration equipment

The following vibration platforms were used in the review studies; 3 studies37-39 used ZEPTOR-med (Scisen GmbH, Germany), study 40 used Galileo 2000 (Novotec, Germany) and 1 study used Fit Massage 21641 (Top elite fit massage. Co, Zhejiang, China), differing from one another in terms of the type of vibration stimulation; the studies of one single WBV session used vibration platforms of the stochastic type, whereas the studies of at least 12 intervention sessions used tilting vibration platforms (fig. 2).

Fig. 2. Whole body vibration devices.

Parameters affecting whole body vibration

Frequency (Hz) and amplitude (mm)

The frequency applied in the stochastic vibration machines was 6 Hz and the amplitude 3 mm37-39, whereas the tilting vibration machines used 6 and 25 Hz with an amplitude varying between 7 and 4 mm40,41.

Knee position and degree of knee flexion

All the reviewed studies reported static position during WBV, while no study detailed the exact degree of knee flexion.

Description of training

WBV training varied between studies, where a single session was used in order to determine the acute effects and studies, where 12 or more WBV sessions were used in order to observe chronic effects. Three studies analyzed the acute effects of WBV37-39, after a single session of 60 s, while 2 studies analyzed the chronic effects after 12 and 30 sessions, respectively, lasting from 60 to 900 s (with a 60-s resting period between series)40,41.

Key measurements and effects

The key measurements refer mainly to HRQoL and postural control values (table 3).

HRQoL

Five articles evaluated the impact of WBV on HRQoL using special questionnaires for each population. The Unified Parkinson's Disease

Ratings Scale (UPDRS)40,41 and the Parkinson's Disease Questionnaire (PDQ-39) were used41.

Postural control

Four studies captured measures related to postural control, balance or gait37,38,40,41. In order to evaluate balance, proprioception and gait, we used measurements such as the functional reach test41, a test of walking 10 m at maximum speed40, the Berg41 and Tinetti40 balance scale, a test of rising, walking and sitting down40 and specific gait parameters, such as speed, cadence, stride length and turning41.

Effects of exposure to whole body vibration

Three37-39 out of the 5 studies reviewed focus on the acute effects of undergoing a single vibration session, and particularly evaluating the effects of postural control37, proprioception39 and PD motor symptoms38 noting improvements in the measurements of postural control with an advanced foot, in tremor, rigidity, bradykinesia, gait and posture. As for chronic effects, two articles studied the effects of medium-term exposure (after 12 and 30 sessions) to WBV40,41, one of them in comparison with a standard therapy40 and the other, comparing with a placebo group41, finding no improvements in any of the measured parameters, except for posturography.

Discussion

The completed systematic review produced a limited number of studies related to the effects on PD obtained by WBV, this being still a very recent topic (the first completed study dates back to 2005), and a great variety in the PICOS approach in the reviewed studies, something which makes it difficult to conduct a meta-analysis. For all the above reasons, the scientific evidence on the subject is limited, yielding a level 3 conformance with CBO53.

The results of the reviewed studies show that after a single WBV session, or after several weeks of training, the final HRQoL score improves in the UPDRS questionnaire, as does the score in the section of the questionnaire dealing with physical parameters. However, this improvement is reminiscent of the one obtained in a placebo group or a group in which a standard physical therapy was continued40,41. The paucity of studies and the modest sample size, allow us to say that there is currently scant evidence concerning the effects of WBV on HRQoL in PD.

In contrast, nearly all the reviewed studies present measurements related to balance, gait and postural control, which are crucial conditions in the course of PD7. The effects of applying a single WBV session on the above parameters remain limited, since only one study reported improvements in terms of postural control37. As for the effects of WBV training below 12 weeks, it was observed that this type of training fails to produce a major improvement in patients, when comparing with a placebo therapy or a standard physical therapy, however, the statistically significant improvements found in the WBV group vis-a-vis the baseline is a sign that this treatment may be useful in PD.

This review presents some limitations. It lacks a standardized criterion for evaluating the level of evidence. Different authors of systematic reviews use different criteria55, and besides, the one and the same author sometimes uses different criteria depending on the study56. The use of different criteria is related to the decision as to whether randomized clinical studies or studies presenting a low methodological quality should be considered, whereby scales of measurement may also vary, and the best method for assessing the risk of bias is also uncertain55.

Data deemed important, but found missing in the original manuscript, had to be requested from the author in charge of correspondence and omitted if not reported.

The search strategy that was used involved the risk of bias, since only articles written in English were searched. Publishing significant rather than non-significant results is easier, and the latter are more likely to appear in national journals, if written in the native language57.

The need to investigate whether all the beneficial effects related to the application of WBV in healthy populations can be extrapolated to PD becomes apparent.

An optimal dose-response study according to disorder and WBV type is urgently needed. Similarly, the cost-effectiveness and cost-utility of various WBV treatments should be determined.

Conclusions

From data disclosed in the present review it appears that WBV may help improve balance, gait, postural control, as well as HRQoL of individuals with PD, however, the paucity of studies, the variety of applied vibration types, measurements provided in the various studies, and interventions performed have all made it difficult to make a comparison between existing PD and WBV studies. In order to clarify these issues, future studies need to be made.

Acknowledgements

This proyect was supported by Enterprising Solutions for Health, S.L.


Correspondence:

B. del Pozo Cruz.

Faculty of Sports Sciences. University of Extremadura. 10071 Caceres, Spain

E-mail: borjadelpozo@unex.es

History of the article:

Received August 14, 2010.

Accepted December 5, 2010.

Bibliography
1
Lees AJ,Hardy J,Revesz T.
Parkinson''s disease.
Lancet. , 373 (2009), pp. 2055-66 http://dx.doi.org/10.1016/S0140-6736(09)60492-X
2
Biskup S,Gerlach M,Kupsch A,Reichmann H,Riederer P,Vieregge P,et al.
Genes associated with Parkinson syndrome.
J Neurol. , 255 Suppl 5 (2008), pp. 8-17 http://dx.doi.org/10.1007/s00415-010-5738-6
3
Pankratz N,Wilk JB,Latourelle JC,DeStefano AL,Halter C,Pugh EW,et al.
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
Hum Genet. , 124 (2009), pp. 593-605 http://dx.doi.org/10.1007/s00439-008-0582-9
4
De Lau LM,Giesbergen PC,de Rijk MC,Hofman A,Koudstaal PJ,Breteler MM.
Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam Study.
Neurology. , 63 (2004), pp. 1240-4
5
Vines JJ,Larumbe R,Gaminde I,Artazcoz MT.
[Incidence of idiopathic and secondary Parkinson disease in Navarre. Population-based case registry].
Neurologia. , 14 (1999), pp. 16-22
6
Lopez-Morinigo JD,Ramos-Ríos R,Martínez-Formoso S,Arrojo-Romero M,Ecenarro-Tome P.
[Parkinson''s disease and obsessive-compulsive spectrum].
Rev Neurol. , 49 (2009), pp. 202-9
7
Larsen JP,Beiske AG,Bekkelund SI,Dietrichs E,Tysnes OB,Vilming ST,et al.
[Motor symptoms in Parkinson disease].
Tidsskr Nor Laegeforen. , 128 (2008), pp. 2068-71
8
Yousefi B,Tadibi V,Fathollahzadeh Khoei A,Montazeri A.
Exercise therapy, quality of life, and activities of daily living in patients with Parkinson disease: a small scale quasi-randomised trial.
9
Goodwin VA,Richards SH,Taylor RS,Taylor AH,Campbell JL.
The effectiveness of exercise interventions for people with Parkinson''s disease: a systematic review and meta-analysis.
Mov Disord. , 23 (2008), pp. 631-40 http://dx.doi.org/10.1002/mds.21922
10
Botzel K,Kraft E.
Strategies for treatment of gait and posture associated deficits in movement disorders: the impact of deep brain stimulation.
Restor Neurol Neurosci. , 28 (2010), pp. 115-22 http://dx.doi.org/10.3233/RNN-2010-0532
11
Di Monaco M,Vallero F,Di Monaco R,Tappero R,Cavanna A.
Type of hip fracture in patients with Parkinson disease is associated with femoral bone mineral density.
Arch Phys Med Rehabil. , 89 (2008), pp. 2297-301 http://dx.doi.org/10.1016/j.apmr.2008.06.016
12
Oliveira MA,Rodrigues AM,Caballero RM,Petersen RD,Shim JK.
Strength and isometric torque control in individuals with Parkinson''s disease.
Exp Brain Res. , 184 (2008), pp. 445-50 http://dx.doi.org/10.1007/s00221-007-1212-9
13
Mak MK,Pang MY.
Balance self-efficacy determines walking capacity in people with Parkinson''s disease.
Mov Disord. , 23 (2008), pp. 1936-9 http://dx.doi.org/10.1002/mds.22251
14
Fertl E,Doppelbauer A,Auff E.
Physical activity and sports in patients suffering from Parkinson''s disease in comparison with healthy seniors.
J Neural Transm Park Dis Dement Sect. , 5 (1993), pp. 157-61
15
Genever RW,Downes TW,Medcalf P.
Fracture rates in Parkinson''s disease compared with age- and gender-matched controls: a retrospective cohort study.
Age Ageing. , 34 (2005), pp. 21-4 http://dx.doi.org/10.1093/ageing/afh203
16
Pressley JC,Louis ED,Tang MX,Cote L,Cohen PD,Glied S,et al.
The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism.
Neurology. , 60 (2003), pp. 87-93
17
Linazasoro G,van Blercom N.
[Treatment of Parkinson disease: therapeutic reserve of the dopaminergic agonist].
Neurologia. , 21 (2006), pp. 365-75
18
Brotchie J,Fitzer-Attas C.
Mechanisms compensating for dopamine loss in early Parkinson disease.
Neurology. , 72 (2009), pp. S32-8 http://dx.doi.org/10.1212/WNL.0b013e318198e0e9
19
Keus SH,Bloem BR,Hendriks EJ,Bredero-Cohen AB,Munneke M.
Evidence-based analysis of physical therapy in Parkinson''s disease with recommendations for practice and research.
Mov Disord. , 22 (2007), pp. 451-60 http://dx.doi.org/10.1002/mds.21244
20
Keus SH,Munneke M,Nijkrake MJ,Kwakkel G,Bloem BR.
Physical therapy in Parkinson''s disease: evolution and future challenges.
Mov Disord. , 24 (2009), pp. 1-14 http://dx.doi.org/10.1002/mds.22141
21
Hoehn MM,Yahr MD.
Parkinsonism: onset, progression and mortality.
Neurology. , 17 (1967), pp. 427-42
22
Watts JJ,McGinley JL,Huxham F,Menz HB,Iansek R,Murphy AT,et al.
Cost effectiveness of preventing falls and improving mobility in people with Parkinson disease: protocol for an economic evaluation alongside a clinical trial.
BMC Geriatr. , 8 (2008), pp. 23 http://dx.doi.org/10.1186/1471-2318-8-23
23
Eggert KM,Reese JP,Oertel WH,Dodel R.
Cost effectiveness of pharmaco-therapies in early Parkinson''s disease.
CNS Drugs. , 22 (2008), pp. 841-60
24
Fraix V,Houeto JL,Lagrange C,Le Pen C,Krystkowiak P,Guehl D,et al.
Clinical and economic results of bilateral subthalamic nucleus stimulation in Parkinson''s disease.
J Neurol Neurosurg Psychiatry. , 77 (2006), pp. 443-9 http://dx.doi.org/10.1136/jnnp.2005.077677
25
Suvorov GA,Schajpak EJ,Kurerov NN,Seidel H,Bluthner R,Schuster U,et al.
[The effect of low-frequency whole-body vibration on the vestibular apparatus].
Z Gesamte Hyg. , 35 (1989), pp. 496-8
26
Goetz CG.
Jean-Martin Charcot and his vibratory chair for Parkinson disease.
Neurology. , 73 (2009), pp. 475-8 http://dx.doi.org/10.1212/WNL.0b013e3181b1640b
27
Seidel H,Heide R.
Long-term effects of whole-body vibration: a critical survey of the literature.
Int Arch Occup Environ Health. , 58 (1986), pp. 1-26
28
De Domenico G.
Tonic vibratory reflex.
What is it? Can we use it? Physiotherapy. , 65 (1979), pp. 44-8
29
Mileva KN,Bowtell JL,Kossev AR.
Effects of low-frequency whole-body vibration on motor-evoked potentials in healthy men.
Experimental Physiology. , 94 (2009), pp. 103-16 http://dx.doi.org/10.1113/expphysiol.2008.042689
30
Cochrane DJ,Stannard SR.
Acute whole body vibration training increases vertical jump and flexibility performance in elite female field hockey players.
Br J Sports Med. , 39 (2005), pp. 860-5 http://dx.doi.org/10.1136/bjsm.2005.019950
31
Goto K,Takamatsu K.
Hormone and lipolytic responses to whole body vibration in young men.
Jap J Physiol. , 55 (2005), pp. 279-84
32
Torvinen S,Kannus P,Sievanen H,Jarvinen TA,Pasanen M,Kontulainen S,et al.
Effect of 8-month vertical whole body vibration on bone, muscle performance, and body balance: a randomized controlled study.
J Bone Miner Res. , 18 (2003), pp. 876-84 http://dx.doi.org/10.1359/jbmr.2003.18.5.876
33
Bruyere O,Wuidart MA,Di Palma E,Gourlay M,Ethgen O,Richy F,et al.
Controlled whole body vibration to decrease fall risk and improve health-related quality of life of nursing home residents.
Arch Phys Med Rehabil. , 86 (2005), pp. 303-7 http://dx.doi.org/10.1016/j.apmr.2004.05.019
34
Jackson KJ,Merriman HL,Vanderburgh PM,Brahler CJ.
Acute effects of whole-body vibration on lower extremity muscle performance in persons with multiple sclerosis.
J Neurol Phys Ther. , 32 (2008), pp. 171-6 http://dx.doi.org/10.1097/NPT.0b013e31818ee760
35
Schuhfried O,Mittermaier C,Jovanovic T,Pieber K,Paternostro-Sluga T.
Effects of whole-body vibration in patients with multiple sclerosis: a pilot study.
Clin Rehabil. , 19 (2005), pp. 834-42
36
Schyns F,Paul L,Finlay K,Ferguson C,Noble E.
Vibration therapy in multiple sclerosis: a pilot study exploring its effects on tone, muscle force, sensation and functional performance.
Clin Rehabil. , 23:771-81. Epub 2009 Jun 26 (2009), http://dx.doi.org/10.1177/0269215508101758
37
Turbanski S,Haas CT,Schmidtbleicher D,Friedrich A,Duisberg P.
Effects of random whole-body vibration on postural control in Parkinson''s disease.
Res Sports Med. , 13 (2005), pp. 243-56 http://dx.doi.org/10.1080/15438620500222588
38
Haas CT,Turbanski S,Kessler K,Schmidtbleicher D.
The effects of random whole-body-vibration on motor symptoms in Parkinson''s disease.
Neuro Rehab. , 21 (2006), pp. 29-36
39
Haas CT,Buhlmann A,Turbanski S,Schmidtbleicher D.
Proprioceptive and sensorimotor performance in Parkinson''s disease.
Res Sports Med. , 14 (2006), pp. 273-87 http://dx.doi.org/10.1080/15438620600985902
40
Ebersbach G,Edler D,Kaufhold O,Wissel J.
Whole body vibration versus conventional physiotherapy to improve balance and gait in Parkinson''s disease.
Arch Phys Med Rehabil. , 89 (2008), pp. 399-403 http://dx.doi.org/10.1016/j.apmr.2007.09.031
41
Arias P,Chouza M,Vivas J,Cudeiro J.
Effect of whole body vibration in Parkinson''s disease: a controlled study.
Mov Disord. , 24 (2009), pp. 891-8 http://dx.doi.org/10.1002/mds.22468
42
Van Nes IJ,Latour H,Schils F,Meijer R,van Kuijk A,Geurts AC.
Long-term effects of 6-week whole-body vibration on balance recovery and activities of daily living in the postacute phase of stroke: a randomized, controlled trial.
43
Van Nes IJ,Geurts AC,Hendricks HT,Duysens J.
Short-term effects of whole-body vibration on postural control in unilateral chronic stroke patients: preliminary evidence.
Am J Phys Med Rehabil. , 83 (2004), pp. 867-73
44
Tihanyi TK,Horvath M,Fazekas G,Hortobagyi T,Tihanyi J.
One session of whole body vibration increases voluntary muscle strength transiently in patients with stroke.
Clin Rehabil. , 21 (2007), pp. 782-93 http://dx.doi.org/10.1177/0269215507077814
45
Semler O,Fricke O,Vezyroglou K,Stark C,Schoenau E.
Preliminary results on the mobility after whole body vibration in immobilized children and adolescents.
J Musculoskelet Neuronal Interact. , 7 (2007), pp. 77-81
46
Ahlborg L,Andersson C,Julin P.
Whole-body vibration training compared with resistance training: effect on spasticity, muscle strength and motor performance in adults with cerebral palsy.
J Rehabil Med. , 38 (2006), pp. 302-8 http://dx.doi.org/10.1080/16501970600680262
47
Rehn B,Lidstrom J,Skoglund J,Lindstrom B.
Effects on leg muscular performance from whole-body vibration exercise: a systematic review.
Scand J Med Sci Sports. , 17 (2007), pp. 2-11 http://dx.doi.org/10.1111/j.1600-0838.2006.00578.x
48
Lings S,Leboeuf-Yde C.
Whole-body vibration and low back pain: a systematic, critical review of the epidemiological literature 1992-1999.
Int Arch Occup Environ Health. , 73 (2000), pp. 290-7
49
Prisby RD,Lafage-Proust MH,Malaval L,Belli A,Vico L.
Effects of whole body vibration on the skeleton and other organ systems in man and animal models: what we know and what we need to know.
Ageing Res Rev. , 7 (2008), pp. 319-29 http://dx.doi.org/10.1016/j.arr.2008.07.004
50
Madou KH,Cronin JB.
The Effects of Whole Body Vibration on Physical and Physiological Capability in Special Populations.
Hong Kong Physiother J. , 26 (2008), pp. 24-38
51
Liberati A,Altman DG,Tetzlaff J,Mulrow C,Gotzsche PC,Ioannidis JP,et al.
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.
PLoS Med. , 6 (2009), pp. e1000100 http://dx.doi.org/10.1371/journal.pmed.1000100
52
Maher CG,Sherrington C,Herbert RD,Moseley AM,Elkins M.
Reliability of the PEDro scale for rating quality of randomized controlled trials.
Phys Ther. , 83 (2003), pp. 713-21
53
Rosenbrand K,Van Croonenborg J,Wittenberg J.
Guideline development.
Stud Health Technol Inform. , 139 (2008), pp. 3-21
54
Liberati A,Altman DG,Tetzlaff J,Mulrow C,Gotzsche PC,Ioannidis JP,et al.
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.
J Clin Epidemiol. , 62:e1-34. Epub 2009 Jul 23 (2009), http://dx.doi.org/10.1016/j.jclinepi.2009.06.006
55
Ferreira PH,Ferreira ML,Maher CG,Refshauge K,Herbert RD,Latimer J.
Effect of applying different "levels of evidence" criteria on conclusions of Cochrane reviews of interventions for low back pain.
J Clin Epidemiol. , 55 (2002), pp. 1126-9
56
Van Tulder M,Malmivaara A,Esmail R,Koes B.
Exercise therapy for low back pain: a systematic review within the framework of the cochrane collaboration back review group.
Spine (Phila Pa 1976). , 25 (2000), pp. 2784-96
57
Higgins JP.
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated Sept 2008]. The Cochrane Collaboration. 2008: [consulted Jul 2009]. Available from: www.
cochrane-handbook. , (org),