Resistance training and immunosenescence of the innate immune system

João Bartholomeu-Neto; David Junger F Alves; Ciro José Brito; Aparecido Pimentel Ferreira; Otávio de Toledo Nóbrega; Cláudio Córdova

doi:10.33155/j.ramd.2018.07.002

João Bartholomeu-Neto Catholic University of Brasılia. Brazil.
David Junger F Alves Catholic University of Brasılia. Brazil.
Ciro José Brito Physical Education Department. Federal University of Juiz de For a. Minas Gerais State. Brazil.
Aparecido Pimentel Ferreira Paulista University. Brasılia. Brazil.
Otávio de Toledo Nóbrega University of Brasılia. Brazil.
Cláudio Córdova Catholic University of Brasılia. Brazil.

DOI: https://doi.org/10.33155/j.ramd.2018.07.002

Keywords: Rsistance Training, Monocytes, Oacrophages, Neutrophils, Elderly

Abstract

Phagocytic cells constitute the first defense line against the diversity of infectious agents. The effects of aging on the immune function – immunosenescence – affect the phagocytic capacity of neutrophils and monocytes/macrophages and result in increased risk to cancer and other diseases. The aim of this review was to assess the functional aspects of the innate system cells in aging. Evidence brought about by this review suggests that resistance training is a useful therapy to mitigate the adverse effects of the innate immune system aging process. Resistance training is consistently recommended as assistent strategy for prevention of the inflamaging and associated chronic diseases, but establishing adequate program is still in demand. In addition, future studies are needed to improve our understanding of the resistance training-induced mechanisms underlying changes in phagocytic activity in the elderly.